| NR3C2 |
| LOCUS ID | 4306 | |||||||||||||
| GENE_SYMBOL | NR3C2 | |||||||||||||
| GENE NAME | nuclear receptor sub | |||||||||||||
| SYNONYMNS | MR, MCR, MLR, NR3C2VIT | |||||||||||||
| CHROMOSOME | 4 | |||||||||||||
| HOMOLOGENE ID | 121495 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal domint pseudohypoaldosteronism type I, a disorder characterized by Urinary salt wasting. Defects in this gene are also associated with early onset hypertension wit |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Aldosterone concentrations and mRNA siglling are associated with an enhanced risk of cardiovascular injury and the incidence of sudden death, and mRNA blockade decreases the risk of cardiovascular events and sudden death in patients with reduced glomerular filtration rate. | 26429402 |
| Insulin resistance and inflammation | 1. Therefore, we consider MR to be a crucial target to prevent metabolic disorders by suppressing inflammasome-mediated chronic inflammation in the adipose tissue and liver under obese conditions. | 28855315 |