| NR4A1 |
| LOCUS ID | 3164 | ||||||||||
| GENE_SYMBOL | NR4A1 | ||||||||||
| GENE NAME | nuclear receptor sub | ||||||||||
| SYNONYMNS | HMR N10 TR3 NP10 GFRP1 NAK-1 NGFIB NUR77 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 1612 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. The basal expression levels of NR4A1, TNF-? and IL-6 were higher in the T2D patients when compared with the controls. | 25289075 |