NR5A2
LOCUS ID2494
GENE_SYMBOLNR5A2
GENE NAMEnuclear receptor sub
SYNONYMNSB1F CPF FTF B1F2 LRH1 LRH-1 FTZ-F1 hB1F-2 FTZ-F1beta
CHROMOSOME1
HOMOLOGENE ID20827
microRNAsNANA
GENE SUMMARY
The protein encoded by this gene is a DNA-binding zinc finger transcription factor and is a member of the fushi tarazu factor-1 subfamily of orphan nuclear receptors. The encoded protein is involved in the expression of genes for hepatitis B virus and cholesterol biosynthesis, and may be an important regulator of embryonic development. [provided by RefSeq, Jun 2016]

OBSERVATIONS

Complication Evidence PMID
Insulin resistance and inflammation1. The associations of the ABO blood group gene and NR5A2 gene variants with PC discovered by recent genome-wide association studies may link insulin resistance, inflammation, and thrombosis to pancreatic carcinogenesis.20647474