| NTF3 |
| LOCUS ID | 4908 | ||||||||||
| GENE_SYMBOL | NTF3 | ||||||||||
| GENE NAME | neurotrophin 3 | ||||||||||
| SYNONYMNS | NT3, HDNF, NGF2, NT-3, NGF-2 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 1896 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintence of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature p |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. expression of NT-3 is reduced in striated muscles in diabetic patients and is related to muscle weakness and neuropathy. We suggest that lack of NT-3 contributes to insufficient re-innervation leading to the loss of muscle strength in diabetic neuropathy. | 19696031 |