| NUCB2 |
| LOCUS ID | 4925 | |||||||||||||
| GENE_SYMBOL | NUCB2 | |||||||||||||
| GENE NAME | nucleobindin 2 | |||||||||||||
| SYNONYMNS | NEFA, HEL-S-109 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 3676 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein with a suggested role in calcium level maintenance, eating regulation in the hypothalamus, and release of tumor necrosis factor from vascular endothelial cells. This protein binds calcium and has EF-folding domains. [provided by RefSeq, Oct 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. In fully adjusted covariates, serum NEFA was an independent risk factor for all-cause mortality (hazard ratio [HR] per log2 increase, 1.22; 95% confidence interval [95% CI], 1.00 to 1.48) and CVD-related death (HR, 1.51; 95% CI, 1.15 to 1.99), including both IHD (HR, 1.51; 95% CI, 1.00 to 2. 32) and AMI mortality (HR, 2. 08; 95% CI, 1.09 to 3. 98). | 25637632 |
| Retinopathy | 1. The difference reached statistical significance in probands with DR and probands without DR (p<0.0001). Nonesterified fatty acid (NEFA) was a risk factor for DR (odds ratio = 2.108, 95% confidence interval 1.077-4.127). | 20306445 |