| OGG1 |
| LOCUS ID | 4968 | ||||||||||
| GENE_SYMBOL | OGG1 | ||||||||||
| GENE NAME | 8-oxoguanine DNA gly | ||||||||||
| SYNONYMNS | HMMH MUTM OGH1 HOGG1 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 1909 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the enzyme responsible for the excision of 8-oxoguanine, a mutagenic base byproduct which occurs as a result of exposure to reactive oxygen. The action of this enzyme includes lyase activity for chain cleavage. Alternative splicing of the C-terminal region of this gene classifies splice variants into two major groups, type 1 and type 2, depending on the last exon of the sequence. Type 1 alternative splice variants end with exon 7 and type 2 end with exon 8. All variants share t |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Global deletion of OGG1 and common OGG1 polymorphisms render mice and humans susceptible to metabolic disease. | 30291284 |