| OLR1 |
| LOCUS ID | 4973 | ||||||||||
| GENE_SYMBOL | OLR1 | ||||||||||
| GENE NAME | oxidized low density | ||||||||||
| SYNONYMNS | LOX1 LOXIN SLOX1 CLEC8A SCARE1 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 1910 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a low density lipoprotein receptor that belongs to the C-type lectin superfamily. This gene is regulated through the cyclic AMP signaling pathway. The encoded protein binds, internalizes and degrades oxidized low-density lipoprotein. This protein may be involved in the regulation of Fas-induced apoptosis. This protein may play a role as a scavenger receptor. Mutations of this gene have been associated with atherosclerosis, risk of myocardial infarction, and may modify the risk |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. PAH patient lung tissue showed enhanced OLR1 immunostaining within plexiform lesions and oxidized LDL accumulation within macrophages. | 30626738 |