| OSM |
| LOCUS ID | 5008 | |||||||||||||
| GENE_SYMBOL | OSM | |||||||||||||
| GENE NAME | oncostatin M | |||||||||||||
| SYNONYMNS | NA | |||||||||||||
| CHROMOSOME | 22 | |||||||||||||
| HOMOLOGENE ID | 10741 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Oncostatin M is a member of a cytokine family that includes leukemia-inhibitory factor, granulocyte colony-stimulating factor, and interleukin 6. This gene encodes a growth regulator which inhibits the proliferation of a number of tumor cell lines. It regulates cytokine production, including IL-6, G-CSF and GM-CSF from endothelial cells. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. OSM induced TEMT by activating the JAK/STAT pathway, which could be inhibited by SOCS. These results indicate that overexpression of SOCS has a therapeutic effect in DN. | 24217922 |
| Insulin resistance and inflammation | 1. Treatment with OSM improved obesity, adipose tissue inflammation, insulin resistance and hepatic steatosis in both mouse models. | 25972231 |