| OSMR |
| LOCUS ID | 9180 | ||||||||||
| GENE_SYMBOL | OSMR | ||||||||||
| GENE NAME | oncostatin M recepto | ||||||||||
| SYNONYMNS | OSMRB PLCA1 IL-31RB OSMRbeta IL-31R-beta | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 2972 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the type I cytokine receptor family. The encoded protein heterodimerizes with interleukin 6 signal transducer to form the type II oncostatin M receptor and with interleukin 31 receptor A to form the interleukin 31 receptor, and thus transduces oncostatin M and interleukin 31 induced signaling events. Mutations in this gene have been associated with familial primary localized cutaneous amyloidosis. Alternatively spliced transcript variants encoding different isoforms |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. OSMR(FKO) mice exhibit increased insulin resistance and adipose tissue inflammation and have increased lean mass, femoral length, and bone volume. | 27325693 |