| P2RX3 |
| LOCUS ID | 5024 | ||||||||||
| GENE_SYMBOL | P2RX3 | ||||||||||
| GENE NAME | purinergic receptor | ||||||||||
| SYNONYMNS | P2X3 | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 1922 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The product of this gene belongs to the family of purinoceptors for ATP. This receptor functions as a ligand-gated ion channel and may transduce ATP-evoked nociceptor activation. Mouse studies suggest that this receptor is important for peripheral pain responses, and also participates in pathways controlling Urinary bladder volume reflexes. It is possible that the development of selective antagonists for this receptor may have a therapeutic potential in pain relief and in the treatment of disord |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Neuropathy | 1. Purinergic receptor signaling transduction pathways might become potential targets for treatment for painful DPN. | 23090494 |