| P2RY1 |
| LOCUS ID | 5028 | ||||||||||
| GENE_SYMBOL | P2RY1 | ||||||||||
| GENE NAME | purinergic receptor | ||||||||||
| SYNONYMNS | P2Y1 | ||||||||||
| CHROMOSOME | 3 | ||||||||||
| HOMOLOGENE ID | 1926 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The product of this gene belongs to the family of G-protein coupled receptors. This family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases, for various adenosine and uridine nucleotides. This receptor functions as a receptor for extracellular ATP and ADP. In platelets binding to ADP leads to mobilization of intracellular calcium ions via activation of phospholipase C, a change in platelet shape, and probably to platelet aggregation. [provide |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. Purinergic receptor signaling transduction pathways might become potential targets for treatment for painful DPN. | 23090494 |