| PAK6 |
| LOCUS ID | 56924 | ||||||||||
| GENE_SYMBOL | PAK6 | ||||||||||
| GENE NAME | p21 protein (Cdc42/R | ||||||||||
| SYNONYMNS | PAK5 | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 23200 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of a family of p21-stimulated serine/threonine protein kinases, which contain an amino-termil Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-termil kinase domain. These kinases function in a number of cellular processes, including cytoskeleton rearrangement, apoptosis, and the mitogen-activated protein (MAP) kinase signaling pathway. The protein encoded by this gene interacts with androgen receptor (AR) and translocates to the nucleus, where it is involved |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. RSK4 and PAK5 may provide a molecular ratiole for late-stage complications in disease, and further studies are warranted to explore these targets for the treatment of diabetic nephro- and neuropathy, frequently seen in patients with HNF4alpha dysfunction. | 15615695 |