| PAQR3 |
| LOCUS ID | 152559 | ||||||||||
| GENE_SYMBOL | PAQR3 | ||||||||||
| GENE NAME | progestin and adipoQ | ||||||||||
| SYNONYMNS | RKTG | ||||||||||
| CHROMOSOME | 4 | ||||||||||
| HOMOLOGENE ID | 71077 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a seven-transmembrane protein localized in the Golgi apparatus in mammalian cells. The encoded protein belongs to the progestin and adipoQ receptor (PAQR) family. This protein functions as a tumor suppressor by inhibiting the Raf/MEK/ERK signaling cascade. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2017] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. PAQR3 overexpression further increased HG-induced FN and ICAM-1 upregulation. | 29930535 |