| PARN |
| LOCUS ID | 5073 | ||||||||||
| GENE_SYMBOL | PARN | ||||||||||
| GENE NAME | poly(A)-specific rib | ||||||||||
| SYNONYMNS | DAN, DKCB6, PFBMFT4 | ||||||||||
| CHROMOSOME | 16 | ||||||||||
| HOMOLOGENE ID | 31098 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a 3'-exoribonuclease, with similarity to the RNase D family of 3'-exonucleases. It prefers poly(A) as the substrate, hence, efficiently degrades poly(A) tails of mRNAs. Exonucleolytic degradation of the poly(A) tail is often the first step in the decay of eukaryotic mRNAs. This protein is also involved in silencing of certain maternal mRNAs during oocyte maturation and early embryonic development, as well as in nonsense-mediated decay (NMD) of mRNAs that conta |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Increased DAN protein (Grem1, Grem2, Grem3, Cerberus, NBL1, SOST, and USAG1) levels are often associated with severe disease-states in adult kidneys. High glucose increases Grem2 expression in kidney cells. Grem2 mediates podocyte apoptosis through Smads. | 30831151 |