| PCK1 |
| LOCUS ID | 5105 | ||||||||||
| GENE_SYMBOL | PCK1 | ||||||||||
| GENE NAME | phosphoenolpyruvate | ||||||||||
| SYNONYMNS | PCKDC PEPCK1 PEPCKC PEPCK-C | ||||||||||
| CHROMOSOME | 20 | ||||||||||
| HOMOLOGENE ID | 1944 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a main control point for the regulation of gluconeogenesis. The cytosolic enzyme encoded by this gene, along with GTP, catalyzes the formation of phosphoenolpyruvate from oxaloacetate, with the release of carbon dioxide and GDP. The expression of this gene can be regulated by insulin, glucocorticoids, glucagon, cAMP, and diet. Defects in this gene are a cause of cytosolic phosphoenolpyruvate carboxykinase deficiency. A mitochondrial isozyme of the encoded protein also has been chara |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Loss of anaplerosis/cataplerosis via genetic knockdown of phosphoenolpyruvate carboxykinase 1 (Pck1) prevented fatty acid-induced rise in oxidative flux, oxidative stress, and inflammation. | 26571396 |