| PDCD4 |
| LOCUS ID | 27250 | ||||||||||
| GENE_SYMBOL | PDCD4 | ||||||||||
| GENE NAME | programmed cell deat | ||||||||||
| SYNONYMNS | H731 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 7879 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene is a tumor suppressor and encodes a protein that binds to the eukaryotic translation initiation factor 4A1 and inhibits its function by preventing RNA binding. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2010] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. High-fat diet (HFD)-fed PDCD4-deficient (PDCD4(-/-)) mice exhibited an absolutely lean phenotype together with improved insulin sensitivity. | 23990362 |