| PDGFA |
| LOCUS ID | 5154 | ||||||||||
| GENE_SYMBOL | PDGFA | ||||||||||
| GENE NAME | platelet-derived gro | ||||||||||
| SYNONYMNS | PDGF1, PDGF-A | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 32055 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the protein family comprised of both platelet-derived growth factors (PDGF) and vascular endothelial growth factors (VEGF). The encoded preproprotein is proteolytically processed to generate platelet-derived growth factor subunit A, which can homodimerize, or altertively, heterodimerize with the related platelet-derived growth factor subunit B. These proteins bind and activate PDGF receptor tyrosine kinases, which play a role in a wide range of developmental process |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. Furthermore, an increased expression of PDGF-A has also been observed in the course of human diabetic nephropathy. | 15517944 |