| PDGFD |
| LOCUS ID | 80310 | ||||||||||
| GENE_SYMBOL | PDGFD | ||||||||||
| GENE NAME | platelet derived gro | ||||||||||
| SYNONYMNS | IEGF, SCDGFB, MSTP036, SCDGF-B | ||||||||||
| CHROMOSOME | 11 | ||||||||||
| HOMOLOGENE ID | 11875 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the platelet-derived growth factor family. The four members of this family are mitogenic factors for cells of mesenchymal origin and are characterized by a core motif of eight cysteines, seven of which are found in this factor. This gene product only forms homodimers and, therefore, does not dimerize with the other three family members. It differs from alpha and beta members of this family in having an unusual N-termil domain, the CUB domain. Two s |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Atherosclerosis | 1. The association between the platelet-derived growth factor D (PDGFD) gene and atherosclerosis has been widely proven, whereas the relationship between the PDGFD gene and ischaemic stroke remains unconfirmed. | 26362023 |