| PDGFRB |
| LOCUS ID | 5159 | ||||||||||
| GENE_SYMBOL | PDGFRB | ||||||||||
| GENE NAME | platelet-derived gro | ||||||||||
| SYNONYMNS | IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 1960 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulati |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. The activation of PDGFR-beta signalling contributes to the progress of diabetic nephropathy, with an increase in oxidative stress and mesangial expansion in CaMKII alpha mice. | 21833587 |