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PDGFRB |
LOCUS ID | 5159 | ||||||||||
GENE_SYMBOL | PDGFRB | ||||||||||
GENE NAME | platelet-derived gro | ||||||||||
SYNONYMNS | IMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1 | ||||||||||
CHROMOSOME | 5 | ||||||||||
HOMOLOGENE ID | 1960 |
microRNAs | NA | NA |
GENE SUMMARY |
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This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulati |
OBSERVATIONS |
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Complication | Evidence | PMID |
Nephropathy | 1. The activation of PDGFR-beta signalling contributes to the progress of diabetic nephropathy, with an increase in oxidative stress and mesangial expansion in CaMKII alpha mice. | 21833587 |