PDGFRB
LOCUS ID5159
GENE_SYMBOLPDGFRB
GENE NAMEplatelet-derived gro
SYNONYMNSIMF1, IBGC4, JTK12, PDGFR, CD140B, PDGFR1, PDGFR-1
CHROMOSOME5
HOMOLOGENE ID1960
microRNAsNANA
GENE SUMMARY
This gene encodes a cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. These growth factors are mitogens for cells of mesenchymal origin. The identity of the growth factor bound to a receptor monomer determines whether the functional receptor is a homodimer or a heterodimer, composed of both platelet-derived growth factor receptor alpha and beta polypeptides. This gene is flanked on chromosome 5 by the genes for granulocyte-macrophage colony-stimulati

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The activation of PDGFR-beta signalling contributes to the progress of diabetic nephropathy, with an increase in oxidative stress and mesangial expansion in CaMKII alpha mice.21833587