| PDLIM2 |
| LOCUS ID | 64236 | ||||||||||
| GENE_SYMBOL | PDLIM2 | ||||||||||
| GENE NAME | PDZ and LIM domain 2 | ||||||||||
| SYNONYMNS | SLIM MYSTIQUE | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 11006 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes a member of the ALP subfamily of PDZ-LIM domain proteins. The encoded protein suppresses anchorage-dependent growth and promotes cell migration and adhesion through interactions with the actin cytoskeleton via the PDZ domain. The encoded protein is also a putative tumor suppressor protein, and decreased expression of this gene is associated with several malignancies including breast cancer and adult T-cell leukemia. Alternatively spliced transcript variants encoding multiple is |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. PDLIM2 deletion resulted in lipid accumulation in liver tissue samples of HFD-induced mice, as evidenced by the significant increase of hepatic TG and TC through reducing the expression of lipogenesis- and transcriptional regulators of lipid metabolism-related genes and enhancing fatty acid oxidation-associated molecules. | 29852170 |