| PDX1 |
| LOCUS ID | 3651 | ||||||||||
| GENE_SYMBOL | PDX1 | ||||||||||
| GENE NAME | pancreatic and duode | ||||||||||
| SYNONYMNS | GSF IPF1 IUF1 IDX-1 MODY4 PDX-1 STF-1 PAGEN1 | ||||||||||
| CHROMOSOME | 13 | ||||||||||
| HOMOLOGENE ID | 175 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a transcriptional activator of several genes, including insulin, somatostatin, glucokinase, islet amyloid polypeptide, and glucose transporter type 2. The encoded nuclear protein is involved in the early development of the pancreas and plays a major role in glucose-dependent regulation of insulin gene expression. Defects in this gene are a cause of pancreatic agenesis, which can lead to early-onset insulin-dependent diabetes mellitus (IDDM), as well as maturit |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In vitro and ex vivo treatments of MIN6 cells and islets isolated from WT mice with DH and GSK restored pancreatic PDX1 expression levels and beta-cell function via PA-induced elevation of proinflammatory chemokine and activation of NF-kB, JNK and p38MAPK signalling pathways. | 30523046 |