| PEBP1 |
| LOCUS ID | 5037 | ||||||||||
| GENE_SYMBOL | PEBP1 | ||||||||||
| GENE NAME | phosphatidylethanola | ||||||||||
| SYNONYMNS | PBP, HCNP, PEBP, RKIP, HCNPpp, PEBP-1, HEL-210, HEL-S-34 | ||||||||||
| CHROMOSOME | 12 | ||||||||||
| HOMOLOGENE ID | 37637 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the phosphatidylethanolamine-binding family of proteins and has been shown to modulate multiple signaling pathways, including the MAP kinase (MAPK), NF-kappa B, and glycogen synthase kinase-3 (GSK-3) signaling pathways. The encoded protein can be further processed to form a smaller cleavage product, hippocampal cholinergic neurostimulating peptide (HCNP), which may be involved in neural development. This gene has been implicated in numerous human cancers and may act |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These suggest that expression levels of RKIP might be regulated by RTX via NF-kappaB. This pathway could play an important role in the development and pathogenesis of DN. | 24065653 |