| PFKFB3 |
| LOCUS ID | 5209 | ||||||||||
| GENE_SYMBOL | PFKFB3 | ||||||||||
| GENE NAME | 6-phosphofructo-2-ki | ||||||||||
| SYNONYMNS | PFK2 IPFK2 iPFK-2 | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 88708 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to a family of bifunctional proteins that are involved in both the synthesis and degradation of fructose-2,6-bisphosphate, a regulatory molecule that controls glycolysis in eukaryotes. The encoded protein has a 6-phosphofructo-2-kinase activity that catalyzes the synthesis of fructose-2,6-bisphosphate (F2,6BP), and a fructose-2,6-biphosphatase activity that catalyzes the degradation of F2,6BP. This protein is required for cell cycle progression and preven |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In wild-type mice, intestine PFKFB3/iPFK2 was increased in response to high-fat diet (HFD) feeding compared with that in mice fed a low-fat diet. | 22841546 |