| PIAS1 |
| LOCUS ID | 8554 | ||||||||||
| GENE_SYMBOL | PIAS1 | ||||||||||
| GENE NAME | protein inhibitor of | ||||||||||
| SYNONYMNS | GBP ZMIZ3 DDXBP1 GU/RH-II | ||||||||||
| CHROMOSOME | 15 | ||||||||||
| HOMOLOGENE ID | 22953 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the protein inhibitor of activated STAT (PIAS) family. PIAS proteins function as SUMO E3 ligases and play important roles in many cellular processes by mediating the sumoylation of target proteins. This protein plays a central role as a transcriptional coregulator of numerous cellular pathways includign the STAT1 and nuclear factor kappaB pathways. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2016] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Overexpression of PIAS1 in inguinal WAT of prediabetic mice significantly improved systemic insulin sensitivity, whereas knockdown of PIAS1 in wild-type mice led to insulin resistance. | 26324179 |