| PIGF |
| LOCUS ID | 5281 | ||||||||||
| GENE_SYMBOL | PIGF | ||||||||||
| GENE NAME | phosphatidylinositol | ||||||||||
| SYNONYMNS | NA | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 31103 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a protein involved in glycosylphosphatidylinositol (GPI)-anchor biosynthesis. The GPI-anchor, a glycolipid containing three mannose molecules in its core backbone, is found on many blood cells where it serves to anchor proteins to the cell surface. The encoded protein and another GPI synthesis protein, PIGO, function in the transfer of ethanolaminephosphate to the third mannose in GPI. Altertively spliced transcript variants encoding different isoforms have been described. [pro |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. These strongly implicate a role for PIGF in the pathogenesis of proliferative diabetic retinopathy. | 9461127 |