| PIK3C2B |
| LOCUS ID | 5287 | ||||||||||
| GENE_SYMBOL | PIK3C2B | ||||||||||
| GENE NAME | phosphatidylinositol | ||||||||||
| SYNONYMNS | C2-PI3K | ||||||||||
| CHROMOSOME | 1 | ||||||||||
| HOMOLOGENE ID | 20582 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to the phosphoinositide 3-kinase (PI3K) family. PI3-kinases play roles in signaling pathways involved in cell proliferation, oncogenic transformation, cell survival, cell migration, and intracellular protein trafficking. This protein contains a lipid kinase catalytic domain as well as a C-terminal C2 domain, a characteristic of class II PI3-kinases. C2 domains act as calcium-dependent phospholipid binding motifs that mediate translocation of proteins to m |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. The top significant SNPs from the discovery samples were selected for replication in the independent cohort. rs3765156 in PIK3C2B was significantly associated with DN in the replication cohort after multiple test. | 30883692 |