| PIK3CA |
| LOCUS ID | 5290 | |||||||||||||
| GENE_SYMBOL | PIK3CA | |||||||||||||
| GENE NAME | phosphatidylinositol | |||||||||||||
| SYNONYMNS | MCM, CWS5, MCAP, PI3K, CLOVE, MCMTC, p110-alpha | |||||||||||||
| CHROMOSOME | 3 | |||||||||||||
| HOMOLOGENE ID | 21249 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Phosphatidylinositol 3-kinase is composed of an 85 kDa regulatory subunit and a 110 kDa catalytic subunit. The protein encoded by this gene represents the catalytic subunit, which uses ATP to phosphorylate PtdIns, PtdIns4P and PtdIns(4,5)P2. This gene has been found to be oncogenic and has been implicated in cervical cancers. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Activation of the PI3K/AKT/mTOR pathway is a crucial molecular event in human clear cell renal cell carcinoma (ccRCC), and is also upregulated in diabetic nephropathy. | 25948777 |
| Insulin resistance and inflammation | 1. An understanding of PI3K dependent wiring of macrophage responses is important as this is involved in various diseases ranging from obesity, type 2 diabetes to chronic inflammatory disease. | 31497027 |