| PLA2G2A |
| LOCUS ID | 5320 | |||||||||||||
| GENE_SYMBOL | PLA2G2A | |||||||||||||
| GENE NAME | phospholipase A2 gro | |||||||||||||
| SYNONYMNS | MOM1, PLA2, PLA2B, PLA2L, PLA2S, PLAS1, sPLA2 | |||||||||||||
| CHROMOSOME | 1 | |||||||||||||
| HOMOLOGENE ID | 254 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the phospholipase A2 family (PLA2). PLA2s constitute a diverse family of enzymes with respect to sequence, function, localization, and divalent cation requirements. This gene product belongs to group II, which contains secreted form of PLA2, an extracellular enzyme that has a low molecular mass and requires calcium ions for catalysis. It catalyzes the hydrolysis of the sn-2 fatty acid acyl ester bond of phosphoglycerides, releasing free fatty acids |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. Secretory phospholipase A2 (s-PLA2) and Lipoprotein-associated PLA2 (Lp-PLA2) are inflammatory enzymes associated with atherosclerosis. | 26282947 |
| Insulin resistance and inflammation | 1. Previously, we found that PLA2G2A protects mice on high-fat diets from weight gain and insulin resistance. | 30020829 |