| PLG |
| LOCUS ID | 5340 | ||||||||||
| GENE_SYMBOL | PLG | ||||||||||
| GENE NAME | plasminogen | ||||||||||
| SYNONYMNS | HAE4 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 55452 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The plasminogen protein encoded by this gene is a serine protease that circulates in blood plasma as an inactive zymogen and is converted to the active protease, plasmin, by several plasminogen activators such as tissue plasminogen activator (tPA), urokinase plasminogen activator (uPA), kallikrein, and factor XII (Hageman factor). The conversion of plasminogen to plasmin involves the cleavage of the peptide bond between Arg-561 and Val-562. Plasmin cleavage also releases the angiostatin protein |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Likewise, increases in plasminogen activator inhibitor-1 levels and fibrin-driven inflammation promote insulin resistance in obesity. | 31132800 |