| PLTP |
| LOCUS ID | 5360 | |||||||||||||
| GENE_SYMBOL | PLTP | |||||||||||||
| GENE NAME | phospholipid transfe | |||||||||||||
| SYNONYMNS | BPIFE, HDLCQ9 | |||||||||||||
| CHROMOSOME | 20 | |||||||||||||
| HOMOLOGENE ID | 4536 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is one of at least two lipid transfer proteins found in human plasma. The encoded protein transfers phospholipids from triglyceride-rich lipoproteins to high density lipoprotein (HDL). In addition to regulating the size of HDL particles, this protein may be involved in cholesterol metabolism. At least two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Atherosclerosis | 1. With regards to the data from this study we hypothesize that serum PLTP is involved in the clearance of postprandial lipoproteins and this process is attenuated in diabetes. Since postprandial lipoproteins are atherogenic, the delay in clearance of these particles could play an important role in the development of atherosclerosis in patients with diabetes mellitus. | 20108050 |
| Insulin resistance and inflammation | 1. In linear models, CRP remained significantly associated with PLTP after adjustment of CVD risk factors and insulin resistance. | 16216472 |