| PODXL |
| LOCUS ID | 5420 | ||||||||||
| GENE_SYMBOL | PODXL | ||||||||||
| GENE NAME | podocalyxin like | ||||||||||
| SYNONYMNS | PC PDX PCLP Gp200 gp135 PCLP-1 PODXL1 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 136790 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the sialomucin protein family. The encoded protein was originally identified as an important component of glomerular podocytes. Podocytes are highly differentiated epithelial cells with interdigitating foot processes covering the outer aspect of the glomerular basement membrane. Other biological activities of the encoded protein include: binding in a membrane protein complex with Na+/H+ exchanger regulatory factor to intracellular cytoskeletal elements, playing a ro |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Loss of PC prevented diet-induced hyperglycemia and insulin resistance but depleted NADPH and glutathione, which exacerbated oxidative stress and correlated with elevated liver inflammation. | 31006591 |