| POLR2D |
| LOCUS ID | 5433 | |||||||||||||
| GENE_SYMBOL | POLR2D | |||||||||||||
| GENE NAME | polymerase (R) II (D | |||||||||||||
| SYNONYMNS | RBP4, RPB16, HSRBP4, HSRPB4 | |||||||||||||
| CHROMOSOME | 2 | |||||||||||||
| HOMOLOGENE ID | 37968 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| This gene encodes the fourth largest subunit of R polymerase II, the polymerase responsible for synthesizing messenger R in eukaryotes. In yeast, this polymerase subunit is associated with the polymerase under suboptimal growth conditions and may have a stress protective role. A sequence for a ribosomal pseudogene is contained within the 3' untranslated region of the transcript from this gene. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Retinopathy | 1. RBP4 may be involved in the process of diabetic retinopathy and may be a novel biomarker for its diagnosis and treatment in diabetic patients. | 20233518 |
| Insulin resistance and inflammation | 1. RBP4 inhibits the signal pathways stimulated by insulin in skeletal muscle cells, resulting in the development of insulin resistance ; It summarizes the current state of knowledge on the potential role of RBP4 in the pathogenesis of cardiovascular diseases, particularly related to insulin resistance. | 28026829 |