| PON3 |
| LOCUS ID | 5446 | ||||||||||||||||
| GENE_SYMBOL | PON3 | ||||||||||||||||
| GENE NAME | paraoxonase 3 | ||||||||||||||||
| SYNONYMNS | NA | ||||||||||||||||
| CHROMOSOME | 7 | ||||||||||||||||
| HOMOLOGENE ID | 37371 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have be |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. Elevated apoA-I glycation and decreased activities of HDL-associated PON1 and PON3, and their interaction are associated with the presence and severity of CAD in patients with T2DM. | 25964115 |
| Atherosclerosis | 1. These suggest that PON3 may be an important protein in preventing atherosclerosis and highlight the importance of antioxidant proteins in the prevention of atherosclerosis in vivo. | 25723336 |
| Insulin resistance and inflammation | 1. In both atherosclerotic phenotypes, serum PON3 concentration was increased, but this was associated with decreased insulin sensitivity in PAD and with inflammation in CAD. | 22153698 |