| PPARD |
| LOCUS ID | 5467 | ||||||||||
| GENE_SYMBOL | PPARD | ||||||||||
| GENE NAME | peroxisome prolifera | ||||||||||
| SYNONYMNS | FAAR,NUC1,NUCI,NR1C2,NUCII,PPARB | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 4544 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) family. PPARs are nuclear hormone receptors that bind peroxisome proliferators and control the size and number of peroxisomes produced by cells. PPARs mediate a variety of biological processes, and may be involved in the development of several chronic diseases, including diabetes, obesity, atherosclerosis, and cancer. This protein is a potent inhibitor of ligand-induced transcription activity of PPAR alpha and PP |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. Feeding PPAR?/?-deficient mice with fructose exacerbated glucose intolerance and led to macrophage infiltration, inflammation, enhanced mRNA and protein levels of CD36, and activation of the JNK pathway in white adipose tissue compared to those of water-fed PPAR?/?-deficient mice. | 25728706 |