| Complication | Evidence | PMID |
| Nephropathy | 1. The Gly482Ser polymorphism of the PPARGC1A gene is associated with DN in Asian Indians. | 19900151 |
| Cardiovascular | 1. We propose that PPARGC1A influences development of type 2 diabetes and CVD via D damage | 18162502 |
| Retinopathy | 1. The protein encoded by this gene is a transcriptional coactivator that regulates the genes involved in energy metabolism. This protein interacts with PPARgamma, which permits the interaction of this protein with multiple transcription factors. This protein can interact with, and regulate the activities of, cAMP response element binding protein (CREB) and nuclear respiratory factors (NRFs). It provides a direct link between exterl physiological stimuli and the regulation of mitochondrial biogenesis, and is a major factor that regulates muscle fiber type determition. This protein may be also involved in controlling blood pressure, regulating cellular cholesterol homoeostasis, and the development of obesity. | 15782399 |
| Neuropathy | 1. PGC-1a and its-regulated transcription factors including TFAM and NRF1, which are master regulators of mitochondrial biogenesis, are significantly downregulated in streptozotocin diabetic dorsal root ganglion (DRG) neurons. | 24423644 |
| Insulin resistance and inflammation | 1. Peroxisome proliferator-activated receptor ? cofactor 1A (PPARGC1A) was 1.75-fold reduced with insulin resistance in muscle, and fatty acid and lipid metabolism and oxidoreductase activity also were downregulated. | 21266331 |
