| PPIA |
| LOCUS ID | 5478 | |||||||||||||
| GENE_SYMBOL | PPIA | |||||||||||||
| GENE NAME | peptidylprolyl isome | |||||||||||||
| SYNONYMNS | CYPA,CYPH,HEL-S-69p | |||||||||||||
| CHROMOSOME | 7 | |||||||||||||
| HOMOLOGENE ID | 134504 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infe |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. The SNP rs6850: A?>?G is associated with increased risk for elevated plasma levels of cyclophilin A and coronary artery disease in patients with and without type 2 diabetes. | 26702934 |
| Nephropathy | 1. Urinary CypA is a good biomarker for early DN detection in humans and it can be released from either mesangial or tubular cells. | 26496315 |