| PRCP |
| LOCUS ID | 5547 | ||||||||||||||||
| GENE_SYMBOL | PRCP | ||||||||||||||||
| GENE NAME | prolylcarboxypeptida | ||||||||||||||||
| SYNONYMNS | PCP, HUMPCP | ||||||||||||||||
| CHROMOSOME | 11 | ||||||||||||||||
| HOMOLOGENE ID | 55867 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the peptidase S28 family of serine exopeptidases. The encoded preproprotein is proteolytically processed to generate the mature lysosomal prolylcarboxypeptidase. This enzyme cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. After 32 weeks, ZDF rats showed continuously altered expression in PRCP and inflammatory markers, which was linked to severe hyperglycemia and nephropathy. | 26362276 |
| Cardiovascular | 1. Study suggests that increased plasma PRCP level is associated with cardiovascular risk factors, such as atherosclerosis, inflammation, and diabetes. | 26362276 |
| Atherosclerosis | 1. Study suggests that increased plasma PRCP level is associated with cardiovascular risk factors, such as atherosclerosis, inflammation, and diabetes. | 26362276 |