| PRDX4 |
| LOCUS ID | 10549 | |||||||||||||
| GENE_SYMBOL | PRDX4 | |||||||||||||
| GENE NAME | peroxiredoxin 4 | |||||||||||||
| SYNONYMNS | PRX-4, AOE372, AOE37-2, HEL-S-97n | |||||||||||||
| CHROMOSOME | X | |||||||||||||
| HOMOLOGENE ID | 4672 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is an antioxidant enzyme and belongs to the peroxiredoxin family. The protein is localized to the cytoplasm. Peroxidases of the peroxiredoxin family reduce hydrogen peroxide and alkyl hydroperoxides to water and alcohol with the use of reducing equivalents derived from thiol-containing donor molecules. This protein has been found to play a regulatory role in the activation of the transcription factor NF-kappaB. [provided by RefSeq, Jul 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Cardiovascular | 1. In , PRDX1, -2, -4, and -6 showed differential correlations with a variety of traditional cardiovascular risk factors. | 25742636 |
| Insulin resistance and inflammation | 1. Our published data have shown that PRDX4 helps prevent the progression of metabolic syndrome by reducing local and systemic oxidative stress and synergistically suppressing steatosis, inflammatory reactions, and/or apoptotic activity. | 29341349 |