| PRKAA1 |
| LOCUS ID | 5562 | ||||||||||
| GENE_SYMBOL | PRKAA1 | ||||||||||
| GENE NAME | protein kinase, AMP- | ||||||||||
| SYNONYMNS | AMPK, AMPKa1 | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 49590 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene belongs to the ser/thr protein kinase family. It is the catalytic subunit of the 5'-prime-AMP-activated protein kinase (AMPK). AMPK is a cellular energy sensor conserved in all eukaryotic cells. The kinase activity of AMPK is activated by the stimuli that increase the cellular AMP/ATP ratio. AMPK regulates the activities of a number of key metabolic enzymes through phosphorylation. It protects cells from stresses that cause ATP depletion by switching off ATP |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. There was haplotype association of PRKAA2 rs10789038-rs2796498-rs2746342 with T2DM susceptibility. In addition, rs2796498 was found to be related to the susceptibility to diabetic nephropathy. | 20332614 |