| PRKCB |
| LOCUS ID | 5579 | |||||||||||||
| GENE_SYMBOL | PRKCB | |||||||||||||
| GENE NAME | protein kinase C bet | |||||||||||||
| SYNONYMNS | PKCB, PRKCB1, PRKCB2, PKC-beta | |||||||||||||
| CHROMOSOME | 16 | |||||||||||||
| HOMOLOGENE ID | 56424 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in cells |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. PRKCB1 is a predictor for worsening of kidney disease in Japanese subjects with type 2 diabetes. | 16567829 |
| Neuropathy | 1. These suggest that chronic hyperglycemia may activate platelet PKCbeta isoform, and that insulin treatment may decrease platelet PKCbeta activity. Finally, not only PKCbeta antagonists, but also glycemic control by insulin may prevent development of diabetic microangiopathy. | 11304414 |