| PRKCE |
| LOCUS ID | 5581 | ||||||||||
| GENE_SYMBOL | PRKCE | ||||||||||
| GENE NAME | protein kinase C, ep | ||||||||||
| SYNONYMNS | PKCE, nPKC-epsilon | ||||||||||
| CHROMOSOME | 2 | ||||||||||
| HOMOLOGENE ID | 48343 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play a distinct role in c |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats. | 20665664 |