| PRKG1 |
| LOCUS ID | 5592 | ||||||||||
| GENE_SYMBOL | PRKG1 | ||||||||||
| GENE NAME | protein kinase, cGMP | ||||||||||
| SYNONYMNS | PKG, cGK, AAT8, cGK1, cGKI, cGK, 1, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha | ||||||||||
| CHROMOSOME | 10 | ||||||||||
| HOMOLOGENE ID | 55964 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by altertive transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRK |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Neuropathy | 1. hyperglycemia substantially upregulates PDE5 expression and that the cGMP/PKG signaling pathway activated by sildefil mediates the beneficial effects of sildefil on diabetic peripheral neuropathy. | 21820491 |