PRKG1
LOCUS ID5592
GENE_SYMBOLPRKG1
GENE NAMEprotein kinase, cGMP
SYNONYMNSPKG, cGK, AAT8, cGK1, cGKI, cGK, 1, PRKG1B, PRKGR1B, cGKI-BETA, cGKI-alpha
CHROMOSOME10
HOMOLOGENE ID55964
microRNAsNANA
GENE SUMMARY
Mammals have three different isoforms of cyclic GMP-dependent protein kinase (Ialpha, Ibeta, and II). These PRKG isoforms act as key mediators of the nitric oxide/cGMP signaling pathway and are important components of many signal transduction processes in diverse cell types. This PRKG1 gene on human chromosome 10 encodes the soluble Ialpha and Ibeta isoforms of PRKG by altertive transcript splicing. A separate gene on human chromosome 4, PRKG2, encodes the membrane-bound PRKG isoform II. The PRK

OBSERVATIONS

Complication Evidence PMID
Neuropathy1. hyperglycemia substantially upregulates PDE5 expression and that the cGMP/PKG signaling pathway activated by sildefil mediates the beneficial effects of sildefil on diabetic peripheral neuropathy.21820491