| PRL |
| LOCUS ID | 5617 | ||||||||||
| GENE_SYMBOL | PRL | ||||||||||
| GENE NAME | prolactin | ||||||||||
| SYNONYMNS | GHA1 | ||||||||||
| CHROMOSOME | 6 | ||||||||||
| HOMOLOGENE ID | 732 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes the anterior pituitary hormone prolactin. This secreted hormone is a growth regulator for many tissues, including cells of the immune system. It may also play a role in cell survival by suppressing apoptosis, and it is essential for lactation. Alternative splicing results in multiple transcript variants that encode the same protein. [provided by RefSeq, Aug 2011] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. In vitro, we demonstrated that hyperglycemia and inflammation stimulated macrophages (human THP-1 cell line and sorted rat ATM) to express PRL, when challenged with different glucose concentrations with or without IL1?. | 24361460 |