| PTGER1 |
| LOCUS ID | 5731 | ||||||||||
| GENE_SYMBOL | PTGER1 | ||||||||||
| GENE NAME | prostaglandin E rece | ||||||||||
| SYNONYMNS | EP1 | ||||||||||
| CHROMOSOME | 19 | ||||||||||
| HOMOLOGENE ID | 738 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a member of the G protein-coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). Through a phosphatidylinositol-calcium second messenger system, G-Q proteins mediate this receptor's activity. Knockout studies in mice suggested a role of this receptor in mediating algesia and in regulation of blood pressure. Studies in mice also suggested that this gene may mediate adrenocorticotropic hormone response to bact |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. potential usefulness of selective EP1 blockade as a novel therapeutic strategy for diabetic nephropathy and also brings a new insight into our understanding of this disease. 2. These data suggest that EP1 activation contributes to diabetic nephropathy progression at several locations, including podocytes, proximal tubule, and the vasculature. 3. The EP1 receptor facilitates the actions of angiotensin II, thereby suggesting that targeting of both the renin-angiotensin system and the EP1 receptor could be beneficial in diabetic nephropathy. | 12089371 |