| PTGER4 |
| LOCUS ID | 5734 | ||||||||||
| GENE_SYMBOL | PTGER4 | ||||||||||
| GENE NAME | prostaglandin E rece | ||||||||||
| SYNONYMNS | EP4, EP4R | ||||||||||
| CHROMOSOME | 5 | ||||||||||
| HOMOLOGENE ID | 20261 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the G-protein coupled receptor family. This protein is one of four receptors identified for prostaglandin E2 (PGE2). This receptor can activate T-cell factor sigling. It has been shown to mediate PGE2 induced expression of early growth response 1 (EGR1), regulate the level and stability of cyclooxygese-2 mR, and lead to the phosphorylation of glycogen synthase kinase-3. Knockout studies in mice suggest that this receptor may be involved in the neot |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Nephropathy | 1. the expression of EP1 and EP3 were both increased and EP4 was lessened in the DN model group compared with normal group, BBR could down-regulate total protein expression of EP1 and EP3 of renal cortex in DN rats and up-regulate the expression of EP4, and there is no significant difference on the expression of EP2 among all groups. | 24488262 |