| PTH |
| LOCUS ID | 5741 | |||||||||||||
| GENE_SYMBOL | PTH | |||||||||||||
| GENE NAME | parathyroid hormone | |||||||||||||
| SYNONYMNS | PTH1 | |||||||||||||
| CHROMOSOME | 11 | |||||||||||||
| HOMOLOGENE ID | 266 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| This gene encodes a member of the parathyroid family of proteins. The encoded preproprotein is proteolytically processed to generate a protein that binds to the parathyroid hormone/parathyroid hormone-related peptide receptor and regulates blood calcium and phosphate levels. Excess production of the encoded protein, known as hyperparathyroidism, can result in hypercalcemia and kidney stones. On the other hand, defective processing of the encoded protein may lead to hypoparathyroidism, which can |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. Comparison of DN group and healthy subjects identified statistically significant difference for the FokI polymorphism in VDR gene (P<10-4) and also for the BstBI polymorphism in PTH gene (P=0,023). | 22777106 |
| Cardiovascular | 1. PAC was independently related to incident cardiovascular mortality exclusively in patients with elevated PTH and vice versa. | 25777071 |