| PTN |
| LOCUS ID | 5764 | ||||||||||
| GENE_SYMBOL | PTN | ||||||||||
| GENE NAME | pleiotrophin | ||||||||||
| SYNONYMNS | HARP HBBM HBNF HBGF8 NEGF1 OSF-1 HB-GAM HBGF-8 HBNF-1 | ||||||||||
| CHROMOSOME | 7 | ||||||||||
| HOMOLOGENE ID | 2117 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene is a secreted heparin-binding growth factor. The protein has significant roles in cell growth and survival, cell migration, angiogenesis and tumorigenesis. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Oct 2016] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. PTN and MK modulate the immune response and/or inflammation in different pathologies characterized by peripheral inflammation associated with insulin resistance, such as aging, and in central disorders characterized by overt neuroinflammation, such as neurodegenerative diseases and endotoxemia. | 31031625 |