| PTPN2 |
| LOCUS ID | 5771 | ||||||||||
| GENE_SYMBOL | PTPN2 | ||||||||||
| GENE NAME | protein tyrosine pho | ||||||||||
| SYNONYMNS | PTN2 PTPT TCPTP TC-PTP TCELLPTP | ||||||||||
| CHROMOSOME | 18 | ||||||||||
| HOMOLOGENE ID | 7497 |
| microRNAs | NA | NA |
| GENE SUMMARY |
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| The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. Members of the PTP family share a highly conserved catalytic motif, which is essential for the catalytic activity. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. Epidermal growth factor receptor and the adaptor protein Shc were reported to be substrates of this PTP, which suggest |
| OBSERVATIONS |
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| Complication | Evidence | PMID |
| Insulin resistance and inflammation | 1. PTPN2 was downregulated in EWAT of diabetic ApoE-/- mice. | 29587266 |