PTX3
LOCUS ID5806
GENE_SYMBOLPTX3
GENE NAMEpentraxin 3, long
SYNONYMNSTSG-14, TNFAIP5
CHROMOSOME3
HOMOLOGENE ID7500
microRNAsNANA
GENE SUMMARY
This gene encodes a member of the pentraxin protein family. The expression of this protein is induced by inflammatory cytokines in response to inflammatory stimuli in several mesenchymal and epithelial cell types, particularly endothelial cells and mononuclear phagocytes. The protein promotes fibrocyte differentiation and is involved in regulating inflammation and complement activation. It also plays a role in angiogenesis and tissue remodeling. The protein serves as a biomarker for several infl

OBSERVATIONS

Complication Evidence PMID
Nephropathy1. The current study provided the first evidence that decreased plasma PTX3 levels are associated with T2DM and DN in Malay men and also suggested that PTX3 may have different effects in DN and chronic kidney diseases. 2. Our findings suggested that PTX3 polymorphisms were associated with an increased risk for DN in Chinese patients with type 2 diabetes.24350299
Retinopathy1. Plasma PTX3 is positively associated with DR development and progression, and may be a more accurate predictor of DR development than hsCRP.25159210
Atherosclerosis1. It is well known that inflammatory biomarkers [high-sensitivity C-reactive protein (hs-CRP), pentraxin3 (PTX3)] and oxidative stress markers [malondialdehyde low-density lipoprotein (MDA-LDL)] are associated with atherosclerotic changes.26162942
Insulin resistance and Inflammation1. PTX3 may therapeutically aid in altering the proinflammatory milieu in obese individuals( low-grade proinflammation that can directly contribute to the development of insulin resistance) and despite elevated expression of PTX3 mRNA observed in adipose tissue, the circulating level of PTX3 is reduced with obesity28400677