| PVT1 |
| LOCUS ID | 5820 | ||||||||||
| GENE_SYMBOL | PVT1 | ||||||||||
| GENE NAME | Pvt1 oncogene (non-p | ||||||||||
| SYNONYMNS | LINC00079, NCR00079 | ||||||||||
| CHROMOSOME | 8 | ||||||||||
| HOMOLOGENE ID | 0 |
| microRNAs | NA | NA |
| GENE SUMMARY |
|---|
| The protein encoded by this gene belongs to a family of phosphatidylinositol kinase-related kinases. These kinases mediate cellular responses to stresses such as D damage and nutrient deprivation. This protein acts as the target for the cell-cycle arrest and immunosuppressive effects of the FKBP12-rapamycin complex. The ANGPTL7 gene is located in an intron of this gene. [provided by RefSeq, Sep 2008] |
| OBSERVATIONS |
|---|
| Complication | Evidence | PMID |
| Nephropathy | 1. These indicate that PVT1 may mediate the development and progression of diabetic nephropathy through mechanisms involving extracellular matrix (ECM) accumulation. | 21526116 |